2021 – present

Lindemann-Perez E, Rodríguez DL, Pérez JC (2024) An approach to analyze spatiotemporal patterns of gene expression at single-cell resolution in Candida albicans infected mouse tongues. mSphere (in press).

Lindemann-Perez E, Pérez JC (2024) Candida albicans natural diversity: A resource to dissect fungal commensalism and pathogenesis. Curr Opin Microbiol 80:102493.

Rodríguez DL, Lindemann-Perez E, Pérez JC (2024) RFX transcription factor in the human associated yeast Candida albicans regulates adhesion to oral epithelium. Mol Microbiol 121: 727-741.

Liang SH, Sircaik S, Dainis J, Kakade P, Penumutchu S, McDonough LD, Chen YH, Frazer C, Schille TB, Allert S, Elshafee O, Hänel M, Mogavero S, Vaishnava S, Cadwell K, Belenky P, Pérez JC, Hube B, Ene IV, Bennett RJ (2024) The hyphal-specific toxin candidalysin promotes fungal gut commensalism. Nature 627: 620-627.

Oneissi M, Cruz MR, Ramírez-Zavala B, Lindemann-Perez E, Morschhäuser J, Garsin DA, Pérez JC (2023) Host-derived reactive oxygen species trigger activation of the Candida albicans transcription regulator Rtg1/3. PLoS Pathog 19:e1011692.

Reuter-Weissenberger P, Meir J, Pérez JC (2021) A fungal transcription regulator of vacuolar function modulates Candida albicans interactions with host epithelial cells. mBio 12: e03020-21.

Pérez JC (2021) The interplay between gut bacteria and the yeast Candida albicans. Gut Microbes 13: e1979877.

Moreno-Velásquez SD, Pérez JC (2021) Imaging and quantification of mRNA molecules at single-cell resolution in the human fungal pathogen Candida albicans. mSphere 6: e00411-21.

Pérez JC (2021) Fungi of the human gut microbiota: Roles and significance. Int J Med Microbiol 311: 151490.

2016 – 2020

Eckstein MT, Moreno-Velásquez SD, Pérez JC (2020) Gut bacteria shape intestinal microhabitats occupied by the fungus Candida albicans. Curr Biol 30: 4799-4807.

Moreno-Velásquez SD, Tint SH, del Olmo Toledo V, Torsin S, De S, Pérez JC (2020) The regulatory proteins Rtg1/3 govern sphingolipid homeostasis in the human associated yeast Candida albicans. Cell Rep 30: 620-629.

Cottier F, Sherrington S, Cockerill S, del Olmo Toledo V, Kissane S, Tournu H, Orsini L, Palmer GE, Pérez JC, Hall RA (2019) Remasking of Candida albicans β-Glucan in response to environmental pH is regulated by quorum sensing. mBio 10: e02347-19.

Pérez JC (2019) Candida albicans dwelling in the mammalian gut. Curr Opin Microbiol 52: 41-46.

Pérez JC (2019) A systematic approach to dissect virulence traits in Candida albicans. mSphere 4: e00258-19.

del Olmo Toledo V, Puccinelli R, Fordyce PM, Pérez JC (2018) Diversification of DNA binding specificities enabled SREBP transcription regulators to expand the repertoire of cellular functions that they govern in fungi. PLoS Genetics 14: e1007884.

Meir J, Hartman E, Eckstein MT, Guiducci E, Kirchner F, Rosenwald A, LeibundGut-Landmann S, Pérez JC (2018) Identification of Candida albicans regulatory genes governing mucosal infection. Cell Microbiol 20: e12841.

Böhm L, Torsin S, Tint SH, Eckstein MT, Ludwig T, Pérez JC (2017) The yeast form of the fungus Candida albicans promotes persistence in the gut of gnotobiotic mice. PLoS Pathog 13: e1006699.

Böhm L, Muralidhara P, Pérez JC (2016) A Candida albicans regulator of disseminated infection operates primarily as a repressor and governs cell surface remodeling. Mol Microbiol 100: 328-344.

2011 – 2015

Pérez JC, Fordyce PM, Lohse MB, Hanson-Smith V, DeRisi JL, Johnson AD (2014) How duplicated transcription regulators can diversify to govern the expression of nonoverlapping sets of genes. Genes Dev 48: 1272-1277.

De S, Pérez JC (2014) Reshuffling transcriptional circuits: How microorganisms adapt to colonize the human body. Transcription 5: e976095.

Pérez JC, Kumamoto CA, Johnson AD (2013) Candida albicans commensalism and pathogenicity are intertwined traits directed by a tightly knit transcriptional regulatory circuit. PLoS Biol 11: e1001510.

Pérez JC, Johnson AD (2013) Regulatory circuits that enable proliferation of the fungus Candida albicans in a mammalian host. PLoS Pathog 9: e1003780.

Fraser HB, Levy S, Chavan A, Shah HB, Kowli S, Pérez JC, Zhou Y, Siegal ML, Sinha H (2012) Polygenic cis-regulatory adaptation in the evolution of yeast pathogenicity. Genome Res 22: 1930-1939.

Zwir I, Latifi T, Pérez JC, Huang H, Groisman EA (2012) The promoter architectural landscape of the Salmonella PhoP regulon. Mol Microbiol 84: 463-485.

2006 – 2010

Pérez JC, Groisman EA (2009) Transcription factor function and promoter architecture govern the evolution of bacterial regulons. Proc Natl Acad Sci USA 106: 4319-4324.

Pérez JC, Groisman EA (2009) Evolution of transcriptional regulatory circuits in bacteria. Cell 138: 233-244.

Kuster DJ, Zhang X, Pérez JC, Marshall GR (2009) Controlling molecular network behavior: molecular design and two-component signal transduction systems. Mazzarella R, Head R. (Eds.) Research Signpost, Kerala.

Pérez JC, Latifi T, Groisman EA (2008) Overcoming H-NS-mediated transcriptional silencing of horizontally-acquired genes by the PhoP and SlyA proteins in Salmonella enterica. J Biol Chem 283: 10773-10783.

Pérez JC, Groisman EA (2007) Acid pH activation of the PmrA/PmrB two-component regulatory system of Salmonella enterica. Mol Microbiol 63: 283-293.

Ogura M*, Pérez JC*, Mittl PRE, Lee HK, Dailide G, Tan S, Ito Y, Secka O, Dailidiene D, Putty K, Berg DE, Kalia A (2007) Helicobacter pylori evolution: lineage-specific adaptations in homologs of eukaryotic Sel1-like genes. PLoS Comput Biol 3: e151.

1999 – 2005

Pastor P, Ezquerra M, Pérez JC, Chakraverty S, Norton J, Racette BA, McKeel D, Perlmutter JS, Tolosa E, Goate AM (2004) Novel haplotypes in 17q21 are associated with progressive supranuclear palsy. Ann Neurol 56: 249-258.

Fuchs BC, Pérez JC, Suetterlin J, Chaudhry SB, Bode BP (2004) Inducible antisense RNA targeting amino acid transporter ATB0/ASCT2 elicits apoptosis in human hepatoma cells. Am J Physiol Gastrointest Liver Physiol 286: G467-G478.

Leone PE, Pérez JC, Morillo S, Paz-y-Miño C (2002) Low incidence of follicular lymphoma and t(14;18)(q32;q21) by polymerase chain reaction analysis: Observations on Ecuadorian patients. Cancer Genet Cytogenet 137: 72-74.

Paz-y-Miño C, Pérez JC, Fiallo F, Leone PE (2002) A polymorphism in the hMSH2 gene (gIVS12-6T>C) associated with non-Hodgkin lymphomas. Cancer Genet Cytogenet 133: 29-33.

Paz-y-Miño C, Pérez JC, Dávalos V, Sánchez ME, Leone PE (2001) Telomeric associations in cigarette smokers exposed to low levels of X-rays. Mutat Res 490: 77-80.

Paz-y-Miño C, Pérez JC, Burgos R, Dávalos V, Leone PE (1999) The DF508 Mutation in Ecuador, South America. Hum Mutat 14: 348-350.